About cco

Manuscript Submission

AME Editing Service

Reprint & Permission


Contact us

Editorial on Targeted Systemic Therapies for Primary and Metastatic Brain Tumors1

Targeted systemic therapies for primary brain tumors
Lyndon Kim

Review Article on Targeted Systemic Therapies for Primary and Metastatic Brain Tumors1

Target treatment with stereotactic radiation for recurrent gliomas
Ayesha S. Ali, Victor E. Chen, Claire Zurlo, James M. Taylor, Christian Fernandez, Wenyin Shi
A narrative review of targeted therapy in meningioma, pituitary adenoma, and craniopharyngioma of the skull base
Nina L. Martinez, Omaditya Khanna, Christopher J. Farrell
A narrative review of targeted therapies in meningioma
Lyndon Kim
Characterization of molecular pathways for targeting therapy in glioblastoma
Naveed Wagle, Minhdan Nguyen, Jose Carrillo, Judy Truong, Lucia Dobrawa, Santosh Kesari

Original Article

Real-world assessment of the effect of impact of tumor size on pathological complete response rates in triple negative breast cancer after neoadjuvant chemotherapy
Bruno Henrique Rala de Paula, Sanjeev Kumar, Fabiola Marques Morosini, Debora Evelyn Martins Calábria Cardoso, Carlos Augusto Moreira de Sousa, Susanne Crocamo

Letter to the Editor

Collateral damage of COVID-19 pandemic on oncology clinical trials
Sri Harsha Tella, Anuhya Kommalapati, Steve R. Alberts, Robert McWilliams, Amit Mahipal

Editorial Commentary

Indolent non-Hodgkin lymphoma treatment in the new drugs era
Luis Miguel Juárez-Salcedo, Samir Dalia
Real-world applications of deep convolutional neural networks in diagnostic cancer imaging
Hesham Elhalawani, Pei Yang, Mohamed Abazeed, Chirag Shah, Abdallah S. R. Mohamed, Charles R. Thomas Jr, Clifton D. Fuller, Reid F. Thompson
Ramucirumab treatment in hepatocellular carcinoma
Federico Longo, Alfredo Carrato
Moving toward multi-dimensional biomarkers in cancer immunotherapy
Max Jameson-Lee, Jason J. Luke


1. The series “Targeted Systemic Therapies for Primary and Metastatic Brain Tumors” was commissioned by the Editorial office, Chinese Clinical Oncology without any sponsorship or funding. Jon Glass served as the unpaid Guest Editor for the series.

Original Article

Prostate carcinoma in transgenic Lewis rats - a tumor model for evaluation of immunological treatments
Laura E. Johnson, Jordan T. Becker, Jason A. Dubovsky, Brian M. Olson, Douglas G. McNeel

Review Article

The spectrum of clinical trials aiming at personalizing medicine
Christophe Le Tourneau, Maud Kamal, Marie Alt, Loic Verlingue, Vincent Servois, Marie-Paule Sablin, Nicolas Servant, Xavier Paoletti
Drug designs fulfilling the requirements of clinical trials aiming at personalizing medicine
Sumithra J. Mandrekar, Daniel J. Sargent
From genomic data analysis to drug development: a new generation of trials using molecular marker assessment in breast cancer
Sophie Doisneau-Sixou, Nadia Harbeck
Melanoma adjuvant therapy
Prashanth M. Thalanayar, Sanjiv S. Agarwala, Ahmad A. Tarhini
Genotyping of cutaneous melanoma
Isabella C. Glitza, Michael A. Davies
Treatment of KIT-mutated metastatic mucosal melanoma
Kevin B. Kim, Anas Alrwas
New approaches in primary central nervous system lymphoma
Eleanor Fraser, Katherine Gruenberg, James L. Rubenstein
Molecular and clinical implementations of ovarian cancer mouse avatar models
Amira A. Zayed, Sumithra J. Mandrekar, Paul Haluska
An overview of the design and conduct of the BATTLE trials
Suyu Liu, J. Jack Lee
Designing a definitive trial for adjuvant targeted therapy in genotype defined lung cancer: the ALCHEMIST trials
Ryan S. Alden, Sumithra J. Mandrekar, Geoffrey R. Oxnard
Risk- and response-adapted strategies for the management of Hodgkin lymphoma
Marcus Remer, Peter W. M. Johnson
Prognostic scores for brain metastasis patients: use in clinical practice and trial design
Vyshak Alva Venur, Manmeet S. Ahluwalia
Strategies for preservation of memory function in patients with brain metastases
Nicholas B. Dye, Vinai Gondi, Minesh P. Mehta
Management of neoplastic meningitis
Patrick Roth, Michael Weller
Design and statistical principles of the SHIVA trial
Xavier Paoletti, Bernard Asselain, Maud Kamal, Nicolas Servant, Philippe Huppé, Ivan Bieche, Christophe Le Tourneau
Autologous tracheal replacement for cancer
Dominique Fabre, Elie Fadel, Sacha Mussot, Frederic Kolb, Nicolas Leymarie, Olaf Mercier, Thierry Le Chevalier, Philippe G. Dartevelle
The staging value of sentinel lymph node biopsy for breast cancer: translating pathologic findings to clinical practice
Jean Bao, Cory Donovan, Alice Chung, Armando E. Giuliano
HER2-positive breast cancer, how far away from the cure?—on the current situation of anti-HER2 therapy in breast cancer treatment and survival of patients
Ning Liao
Training of breast surgical oncologists
Mediget Teshome, Henry M. Kuerer
The way to precision medicine of our team
Fengrui Xu, Xiaodi Wang, Zefei Jiang
Genetic testing for hereditary breast cancer in Asia—moving forward
Ava Kwong


Can EGFR mutation status evolve with chemotherapy?
Eric S. Kim, David J. Stewart, Alok A. Khorana

Review Articles

Prevention of colorectal cancer and dietary management
Ningqi Hou, Dezheng Huo, James J. Dignam
Stage II colon cancer
David N. Church, Rachel Midgley, David J. Kerr
Mining the ACCENT database: a review and update
Lindsay A. Renfro, Qian Shi, Daniel J. Sargent
Status of hepatocellular carcinoma in South Korea
Seung Kew Yoon, Hoo Geun Chun

Statistics in Oncology Clinical Trials

Adaptive randomized phase II design for biomarker threshold selection and independent evaluation
Lindsay A. Renfro, Christina M. Coughlin, Axel M. Grothey, Daniel J. Sargent
Adaptive clinical trial designs in oncology
Yong Zang, J. Jack Lee
Statistical aspect of translational and correlative studies in clinical trials
Herbert Pang, Xiaofei Wang

Updates on Surgical Oncology

Clinical trials in lung cancer surgery and research cooperation
Wen-Zhao Zhong, Hao-Ran Zhai, Yi-Long Wu

Below are the latest Chinese Clinical Oncology articles published online ahead of print publication.