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Original Article

A prospective cohort study of TIMP1 as prognostic biomarker in gastric and colon cancer
Filipa Castro Macedo, Nuno Cunha, Tatiana Cunha Pereira, Rita Felix Soares, Ana Raquel Monteiro, Nuno Bonito, Frederico Valido, Gabriela Sousa
Chinese Clinical Oncology
High local control and low ocular toxicity using ultra-low-dose “boom-boom” radiotherapy for indolent orbital lymphoma
Sanjna Shelukar, Christian Fernandez, Zeynep Bas, Lydia Komarnicky, Sara E. Lally, Carol L. Shields, Adam Binder, Pierluigi Porcu, Onder Alpdogan, Ubaldo Martinez-Outschoorn, Wenyin Shi
Chinese Clinical Oncology

Review Article

A patient-centered, multidisciplinary approach to treating borderline resectable pancreatic adenocarcinoma
Caitlin A. Hester, Matthew H. G. Katz
Chinese Clinical Oncology
Proton radiotherapy for glioma and glioblastoma
Kevin M. Goff, Chuqi Zheng, Michelle Alonso-Basanta
Chinese Clinical Oncology
Palliative interventions for patients with advanced gastric cancer: a systematic review
Kimberly Kopecky, Olivia Monton, Lori Rosman, Fabian Johnston
Chinese Clinical Oncology

Editorial Commentary

GEMSTONE-302: “If you keep doing the same thing you get the same result”
Mengni Guo, Jieying Liu, Tarek Mekhail, Mark A. Socinski
Chinese Clinical Oncology
The role of traditional, complementary, and alternative medicine in cancer care in the Philippines
Ma. Veronica Pia N. Arevalo, Janine Patricia G. Robredo, Sary Valenzuela, Frances Dominique Velasco Ho, Nicole Rose I. Alberto, Isabelle Rose I. Alberto, Madeleine Nicole G. Bernardo, Katherine Donatela Manlongat, Ann Meredith U. Garcia, Jaime Z. Galvez Tan, Edward Christopher Dee, Michelle Ann B. Eala
Chinese Clinical Oncology


1. The series “Interviews with Outstanding Guest Editors” was commissioned by the editorial office, Chinese Clinical Oncology without any funding or sponsorship.

Guidelines and Expert Consensus

Guidelines on the diagnosis and treatment of primary liver cancer (2011 edition)
Primary Liver Cancer Diagnosis Treatment Expert Panel


EGFR mutation in lung cancer: tumor heterogeneity and the impact of chemotherapy
Jair Bar, Damien Urban, Roni Borshtein, Hovav Nechushtan, Amir Onn

Original Article

Prostate carcinoma in transgenic Lewis rats - a tumor model for evaluation of immunological treatments
Laura E. Johnson, Jordan T. Becker, Jason A. Dubovsky, Brian M. Olson, Douglas G. McNeel

Review Article

The spectrum of clinical trials aiming at personalizing medicine
Christophe Le Tourneau, Maud Kamal, Marie Alt, Loic Verlingue, Vincent Servois, Marie-Paule Sablin, Nicolas Servant, Xavier Paoletti
Drug designs fulfilling the requirements of clinical trials aiming at personalizing medicine
Sumithra J. Mandrekar, Daniel J. Sargent
From genomic data analysis to drug development: a new generation of trials using molecular marker assessment in breast cancer
Sophie Doisneau-Sixou, Nadia Harbeck
Melanoma adjuvant therapy
Prashanth M. Thalanayar, Sanjiv S. Agarwala, Ahmad A. Tarhini
Genotyping of cutaneous melanoma
Isabella C. Glitza, Michael A. Davies
Treatment of KIT-mutated metastatic mucosal melanoma
Kevin B. Kim, Anas Alrwas
New approaches in primary central nervous system lymphoma
Eleanor Fraser, Katherine Gruenberg, James L. Rubenstein
Molecular and clinical implementations of ovarian cancer mouse avatar models
Amira A. Zayed, Sumithra J. Mandrekar, Paul Haluska
An overview of the design and conduct of the BATTLE trials
Suyu Liu, J. Jack Lee
Designing a definitive trial for adjuvant targeted therapy in genotype defined lung cancer: the ALCHEMIST trials
Ryan S. Alden, Sumithra J. Mandrekar, Geoffrey R. Oxnard
Risk- and response-adapted strategies for the management of Hodgkin lymphoma
Marcus Remer, Peter W. M. Johnson
Prognostic scores for brain metastasis patients: use in clinical practice and trial design
Vyshak Alva Venur, Manmeet S. Ahluwalia
Strategies for preservation of memory function in patients with brain metastases
Nicholas B. Dye, Vinai Gondi, Minesh P. Mehta
Management of neoplastic meningitis
Patrick Roth, Michael Weller
Design and statistical principles of the SHIVA trial
Xavier Paoletti, Bernard Asselain, Maud Kamal, Nicolas Servant, Philippe Huppé, Ivan Bieche, Christophe Le Tourneau
Autologous tracheal replacement for cancer
Dominique Fabre, Elie Fadel, Sacha Mussot, Frederic Kolb, Nicolas Leymarie, Olaf Mercier, Thierry Le Chevalier, Philippe G. Dartevelle
The staging value of sentinel lymph node biopsy for breast cancer: translating pathologic findings to clinical practice
Jean Bao, Cory Donovan, Alice Chung, Armando E. Giuliano
HER2-positive breast cancer, how far away from the cure?—on the current situation of anti-HER2 therapy in breast cancer treatment and survival of patients
Ning Liao
Training of breast surgical oncologists
Mediget Teshome, Henry M. Kuerer
The way to precision medicine of our team
Fengrui Xu, Xiaodi Wang, Zefei Jiang
Genetic testing for hereditary breast cancer in Asia—moving forward
Ava Kwong


Can EGFR mutation status evolve with chemotherapy?
Eric S. Kim, David J. Stewart, Alok A. Khorana

Review Articles

Prevention of colorectal cancer and dietary management
Ningqi Hou, Dezheng Huo, James J. Dignam
Stage II colon cancer
David N. Church, Rachel Midgley, David J. Kerr
Mining the ACCENT database: a review and update
Lindsay A. Renfro, Qian Shi, Daniel J. Sargent
Status of hepatocellular carcinoma in South Korea
Seung Kew Yoon, Hoo Geun Chun

Statistics in Oncology Clinical Trials

Adaptive randomized phase II design for biomarker threshold selection and independent evaluation
Lindsay A. Renfro, Christina M. Coughlin, Axel M. Grothey, Daniel J. Sargent
Adaptive clinical trial designs in oncology
Yong Zang, J. Jack Lee
Statistical aspect of translational and correlative studies in clinical trials
Herbert Pang, Xiaofei Wang

Updates on Surgical Oncology

Clinical trials in lung cancer surgery and research cooperation
Wen-Zhao Zhong, Hao-Ran Zhai, Yi-Long Wu

Below are the latest Chinese Clinical Oncology articles published online ahead of print publication.

Editorial Commentary

Interviews with Outstanding Guest Editors