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Editorial on the Modern Approaches to the Management of Brain Metastases1

Modern approaches to the management of brain metastases: embracing a multi-modal paradigm
Balamurugan Vellayappan, Jonathan P. S. Knisely, Simon S. Lo, Kevin Shiue
Chinese Clinical Oncology

Review Article on the Modern Approaches to the Management of Brain Metastases1

Brain metastasis prognostic nomograms and brain metastasis velocity: a narrative review
Mohammed Abdulhaleem, Jimmy Ruiz, Christina Cramer, Fei Xing, Hui Wen Lo, Jing Su, Michael D. Chan
Chinese Clinical Oncology
Management of complications from brain metastasis treatment: a narrative review
Kevin Diao, Alan J. Sosa, Gabriel Zada, Seema Nagpal, Eric L. Chang
Chinese Clinical Oncology
Radiation therapy in the prevention and management of brain metastases in patients with small cell lung cancer: a narrative review
Eric Hau, Rebecca Lim, Shalini Vinod, Najmun Nahar, Harriet Gee, Mark B. Pinkham
Chinese Clinical Oncology
Risk-reduction strategies for late complications arising from brain metastases treated with radiotherapy: a narrative review
Chen’en Ye, Pooja Handa, Arjun Sahgal, Simon Lo, Balamurugan Vellayappan
Chinese Clinical Oncology
Literature review of management of brain metastases from germ cell tumors
Amy Le, Mona Arbab, Nabil Adra, James C. Miller, Gordon A. Watson, Kevin Shiue
Chinese Clinical Oncology
Optimal management of brainstem metastases: a narrative review
Joan Y. Lee, Danielle A. Cunningham, Erin S. Murphy, Samuel T. Chao, John H. Suh
Chinese Clinical Oncology
The modern management of untreated large (>2 cm) brain metastases: a narrative review
Bryce J. Thomsen, Hany Soliman
Chinese Clinical Oncology
Novel approaches to the management of patients with 5–15 brain metastases: a narrative review
Alexandra M. Giantini-Larsen, Rupa Gopalan Juthani, Susan C. Pannullo, Jonathan P. S. Knisely
Chinese Clinical Oncology


1. The series “The Modern Approaches to the Management of Brain Metastases” was commissioned by the Editorial office, Chinese Clinical Oncology without any sponsorship or funding. Drs. Simon S. Lo, Balamurugan Vellayappan, Kevin Shiue and Jonathan Knisely served as the unpaid Guest Editors for the series.

Original Article

Prostate carcinoma in transgenic Lewis rats - a tumor model for evaluation of immunological treatments
Laura E. Johnson, Jordan T. Becker, Jason A. Dubovsky, Brian M. Olson, Douglas G. McNeel

Review Article

The spectrum of clinical trials aiming at personalizing medicine
Christophe Le Tourneau, Maud Kamal, Marie Alt, Loic Verlingue, Vincent Servois, Marie-Paule Sablin, Nicolas Servant, Xavier Paoletti
Drug designs fulfilling the requirements of clinical trials aiming at personalizing medicine
Sumithra J. Mandrekar, Daniel J. Sargent
From genomic data analysis to drug development: a new generation of trials using molecular marker assessment in breast cancer
Sophie Doisneau-Sixou, Nadia Harbeck
Melanoma adjuvant therapy
Prashanth M. Thalanayar, Sanjiv S. Agarwala, Ahmad A. Tarhini
Genotyping of cutaneous melanoma
Isabella C. Glitza, Michael A. Davies
Treatment of KIT-mutated metastatic mucosal melanoma
Kevin B. Kim, Anas Alrwas
New approaches in primary central nervous system lymphoma
Eleanor Fraser, Katherine Gruenberg, James L. Rubenstein
Molecular and clinical implementations of ovarian cancer mouse avatar models
Amira A. Zayed, Sumithra J. Mandrekar, Paul Haluska
An overview of the design and conduct of the BATTLE trials
Suyu Liu, J. Jack Lee
Designing a definitive trial for adjuvant targeted therapy in genotype defined lung cancer: the ALCHEMIST trials
Ryan S. Alden, Sumithra J. Mandrekar, Geoffrey R. Oxnard
Risk- and response-adapted strategies for the management of Hodgkin lymphoma
Marcus Remer, Peter W. M. Johnson
Prognostic scores for brain metastasis patients: use in clinical practice and trial design
Vyshak Alva Venur, Manmeet S. Ahluwalia
Strategies for preservation of memory function in patients with brain metastases
Nicholas B. Dye, Vinai Gondi, Minesh P. Mehta
Management of neoplastic meningitis
Patrick Roth, Michael Weller
Design and statistical principles of the SHIVA trial
Xavier Paoletti, Bernard Asselain, Maud Kamal, Nicolas Servant, Philippe Huppé, Ivan Bieche, Christophe Le Tourneau
Autologous tracheal replacement for cancer
Dominique Fabre, Elie Fadel, Sacha Mussot, Frederic Kolb, Nicolas Leymarie, Olaf Mercier, Thierry Le Chevalier, Philippe G. Dartevelle
The staging value of sentinel lymph node biopsy for breast cancer: translating pathologic findings to clinical practice
Jean Bao, Cory Donovan, Alice Chung, Armando E. Giuliano
HER2-positive breast cancer, how far away from the cure?—on the current situation of anti-HER2 therapy in breast cancer treatment and survival of patients
Ning Liao
Training of breast surgical oncologists
Mediget Teshome, Henry M. Kuerer
The way to precision medicine of our team
Fengrui Xu, Xiaodi Wang, Zefei Jiang
Genetic testing for hereditary breast cancer in Asia—moving forward
Ava Kwong


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Prevention of colorectal cancer and dietary management
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Stage II colon cancer
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Mining the ACCENT database: a review and update
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Status of hepatocellular carcinoma in South Korea
Seung Kew Yoon, Hoo Geun Chun

Statistics in Oncology Clinical Trials

Adaptive randomized phase II design for biomarker threshold selection and independent evaluation
Lindsay A. Renfro, Christina M. Coughlin, Axel M. Grothey, Daniel J. Sargent
Adaptive clinical trial designs in oncology
Yong Zang, J. Jack Lee
Statistical aspect of translational and correlative studies in clinical trials
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Updates on Surgical Oncology

Clinical trials in lung cancer surgery and research cooperation
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Below are the latest Chinese Clinical Oncology articles published online ahead of print publication.

Review Article