TY - JOUR AU - Krempley, Benjamin D. AU - Yu, Kenneth H. PY - 2017 TI - Preclinical models of pancreatic ductal adenocarcinoma JF - Chinese Clinical Oncology; Vol 6, No 3 (June 30, 2017): Chinese Clinical Oncology (Pancreas Adenocarcinoma-I-Guest Editors: Eileen M. O’Reilly, Lei Zheng) Y2 - 2017 KW - N2 - Unlike many other cancers, pancreatic ductal adenocarcinoma (PDAC) has seen only incremental improvement in mortality despite significant advances in our understanding of the underlying biology. A primary obstacle to progress has been our inability to properly model PDAC in a preclinical setting. PDAC is difficult to study because of its genetic heterogeneity, intricate stromal microenvironment, and complex interplay with our immune system. Finding a model that properly accounts for all these criteria remains difficult. This review summarizes the five primary models currently in use: human PDAC cell line, cell line xenograft, patient derived xenograft, genetically engineered mouse model (GEMM), and organoids. We delve into the advantages of disadvantages of each model, while discussing how each model has been or could be used in the preclinical setting. UR - https://cco.amegroups.org/article/view/15430