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β-catenin and SKP2 proteins as predictors of grade and stage of non-muscle invasive urothelial bladder carcinoma

  
@article{CCO9339,
	author = {Eid Elsherif and Tarek Abdel Elbaky and Fatma Elserafy and Noha Elkady and Marwa Dawood and Mohamed Abdel Gaber and Atef Badawy and Mohamed El Gharabawy},
	title = {β-catenin and SKP2 proteins as predictors of grade and stage of non-muscle invasive urothelial bladder carcinoma},
	journal = {Chinese Clinical Oncology},
	volume = {5},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {Background: To evaluate the expression of beta-catenin (β-catenin) and SKP2 proteins in superficial bladder cancer cases and their correlation with tumor grade and stage.
Methods: After institutional review board approval, we retrospectively evaluated the expression of β-catenin and SKP2 proteins in tissue specimens from patients with non-muscle invasive bladder cancer (NMIBC) and compared their results with a cohort of chronic nonspecific cystitis’s. Then we and explored these markers association with tumor grade and stage.
Results: A total of 40 patients were retrospectively identified, 50% was NMIBC and the rest were chronic nonspecific cystitis. β-catenin was expressed in 18 (90%) patients of the NMIBC group in comparison to 14 (70%) of the control group with (P=0.1), while SKP2 protein was only expressed in NMIBC groups (P=0.03). A statistically significant correlation was identified between nucleocytoplasmic localization of β-catenin and SKP2 with tumor grade, stage.
Conclusions: β-catenin and SKP2 expression are providing promising results for differentiating higher grade and stage non muscle invasive bladder cancers.},
	issn = {2304-3873},	url = {http://cco.amegroups.com/article/view/9339}
}