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Harnessing the innate immune system to treat cancer: enhancement of antibody-dependent cellular cytotoxicity with anti-CD137 Ab

  
@article{CCO9239,
	author = {Atsushi Yonezawa and Cariad Chester and Narendiran Rajasekaran and Holbrook E. Kohrt},
	title = {Harnessing the innate immune system to treat cancer: enhancement of antibody-dependent cellular cytotoxicity with anti-CD137 Ab},
	journal = {Chinese Clinical Oncology},
	volume = {5},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {Background: Monoclonal antibodies are an invaluable therapeutic class when it comes to cancer therapy. One of the primary mechanisms of anti-tumor activity of monoclonal antibodies is antibody dependent cell-mediated cytotoxicity (ADCC) mediated by natural killer (NK) cells. Innate immune effector cells play important roles in generating and maintaining antitumor immunity to enhance ADCC.
Methods: Efficacy of anti-CD137 mAb was examined by in vitro and in vivo experiments. Clinical trials of anti-CD137 mAb are also on-going.
Results: CD137 is a costimulatory receptor that belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD137 is expressed on T cell, activated NK cells and other immune cells. We recently showed that an agonistic anti-CD137 mAb activates NK cells, resulting in increased ADCC against cancer cells. Anti-CD137 agonistic mAb therapy may both increase ADCC due to mAb-activated NK cells and promote the proliferation and cytotoxicity of antigen-specific T cells induced by mAb treatment.
Conclusions: We discuss some of the promising strategies that could potentially enhance ADCC with anti-CD137 mAbs.},
	issn = {2304-3873},	url = {http://cco.amegroups.com/article/view/9239}
}