%0 Journal Article %T Targeted therapy in non-small cell lung cancer: a focus on epidermal growth factor receptor mutations %A Milano, GĂ©rard A. %J Chinese Clinical Oncology %D 2015 %B 2015 %9 %! Targeted therapy in non-small cell lung cancer: a focus on epidermal growth factor receptor mutations %K %X The main molecular targeting of lung cancer [non-small cell lung cancer (NSCLC)] concerns mutations of epidermal growth factor receptor (EGFR). The awaited responsiveness of tumors carrying these mutations is high with for instance 60% to 80% with tyrosine kinase inhibitors hitting EGFR mutations. The EGFR T790M as a secondary mutation is responsible for the occurrence of a resistance phenomenon. A multitude of drugs have been produced and tested with the property of a specific binding at the EGFR T790M site. There is currently an evolution oriented to a robust genotyping methods allowing the identification of given molecular anomalies (pyrosenquencing for instance) towards the consideration of a much larger set of molecular anomalies under the form of a global genotyping realized with the use of next-generation sequencing (NGS). This phase of whole genome analysis necessitates the introduction of a specialized staff for data treatment. A possible substitution plasma/tumor for the mutation analyses is perceptible in lung cancer, a preference being however given to the intratumoral direct investigation when this is feasible. EGFR mutations as targetable anomalies are illustrative examples, that the management of NSCLC is currently drawing a significant benefit from personalized therapy. %U https://cco.amegroups.org/article/view/8683 %V 4 %N 4 %P 47 %@ 2304-3873