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Targeted therapy in non-small cell lung cancer: a focus on epidermal growth factor receptor mutations

  
@article{CCO8683,
	author = {GĂ©rard A. Milano},
	title = {Targeted therapy in non-small cell lung cancer: a focus on epidermal growth factor receptor mutations},
	journal = {Chinese Clinical Oncology},
	volume = {4},
	number = {4},
	year = {2015},
	keywords = {},
	abstract = {The main molecular targeting of lung cancer [non-small cell lung cancer (NSCLC)] concerns mutations of epidermal growth factor receptor (EGFR). The awaited responsiveness of tumors carrying these mutations is high with for instance 60% to 80% with tyrosine kinase inhibitors hitting EGFR mutations. The EGFR T790M as a secondary mutation is responsible for the occurrence of a resistance phenomenon. A multitude of drugs have been produced and tested with the property of a specific binding at the EGFR T790M site. There is currently an evolution oriented to a robust genotyping methods allowing the identification of given molecular anomalies (pyrosenquencing for instance) towards the consideration of a much larger set of molecular anomalies under the form of a global genotyping realized with the use of next-generation sequencing (NGS). This phase of whole genome analysis necessitates the introduction of a specialized staff for data treatment. A possible substitution plasma/tumor for the mutation analyses is perceptible in lung cancer, a preference being however given to the intratumoral direct investigation when this is feasible. EGFR mutations as targetable anomalies are illustrative examples, that the management of NSCLC is currently drawing a significant benefit from personalized therapy.},
	issn = {2304-3873},	url = {http://cco.amegroups.com/article/view/8683}
}