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The current design of oncology phase I clinical trials: progressing from algorithms to statistical models

  
@article{CCO3488,
	author = {Thomas M. Braun},
	title = {The current design of oncology phase I clinical trials: progressing from algorithms to statistical models},
	journal = {Chinese Clinical Oncology},
	volume = {3},
	number = {1},
	year = {2014},
	keywords = {},
	abstract = {In this article we examine how phase I trial designs for anti-cancer agents have developed over the past few decades. We review the use of algorithmic, relatively non- statistical designs, and then describe nonparametric and parametric statistically-driven designs that have better operating characteristics than algorithmic designs. We then follow with a description of how the original parametric design, known as the continual reassessment method (CRM), has been generalized and expanded to create designs for many complex settings that occur in early-phase oncology trials. We conclude with a discussion of outstanding issues and controversies that continue to exist with phase I trial designs.},
	issn = {2304-3873},	url = {http://cco.amegroups.com/article/view/3488}
}