TY - JOUR AU - Tan, Chun Jek AU - Yang, Jia-Lin AU - Crowe, Philip AU - Goldstein, David PY - 2013 TI - Targeted therapy in soft tissue sarcoma—a novel direction in therapeutics JF - Chinese Clinical Oncology; Vol 2, No 3 (September 30, 2013): Chinese Clinical Oncology Y2 - 2013 KW - N2 - Inherent or acquired resistance to chemotherapy is a significant problem in the treatment of soft tissue sarcomas. Over the past decade, the discovery and characterization of aberrant signaling pathways and the identification of agents that can specifically target them has led to their introduction as novel treatment options in soft-tissue sarcomas (STS). Trials of monotherapy with targeted agents have shown results below expectations often because of activation of alternative signaling pathways. This review examines the potential for tactical combinations of these drugs to overcome this problem. UR - https://cco.amegroups.org/article/view/2804