Article Abstract

Sonic hedgehog signaling pathway and gallbladder cancer: targeting with precision medicine approach

Authors: Naoko Takebe, Sherry X. Yang


Gallbladder cancer is a rare disease with only about 20% of cases diagnosed in early stages. According to the American College of Surgeons/American Cancer Society National Cancer Database in the AJCC Cancer Staging Manual [2010], 5-year survival rate is only 28% for patients with stage II gallbladder cancer and single digit in stage III/IV gallbladder cancers ( It is managed by radiation therapy and chemotherapy for patients with unresectable disease in late stages and no targeted therapy are available. Thus, novel treatment approaches are needed in gallbladder cancer.