Interactions of multiple gene alterations in colorectal liver metastases

Yoshikuni Kawaguchi, Jenilette D. Velasco, Elsa M. Arvide, Steven H. Wei, Jean-Nicolas Vauthey


The advancements in next generation sequencing have expanded the information available in clinical practice. Alterations of TP53, APC, RAS, PIK3CA, and SMAD4 are present in more than 10% of patients with colorectal liver metastases (CLM). Of these genes, TP53, RAS and SMAD4 were associated with worse survival in patients undergoing CLM resection. Testing multiple gene alterations provides a more precise prognosis for patients undergoing CLM resection and may be useful for better clinical decision making