Vitamin E in prevention against hepatocellular carcinoma: right type, right dose and right population

Globally, cancer has surpassed cardiovascular disease as the leading cause of death. In 2008, more than 7.5 million deaths are attributable to malignant diseases worldwide (1). To the general public, cancer prevention has always been a topic of concern, and strategies such as dietary modification or the intake of health supplements have been thoroughly investigated in the past. Amongst all the natural health supplements, vitamin E is probably the most intensively studied cancer preventive agent because of its renowned anti-oxidant property.